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Our laboratory is broadly interested in elucidating the genetics of individuality. We are particularly interested in the identification and functional characterization of genes influencing an individual's innate susceptibility to various diseases, in the interaction between genes and the environment, and in the biological role of the Erbb gene family. Although mouse genetics is our predominant research tool, we are also actively using complementary molecular and proteomic tools. The approach we are taking to study indiviudal variation is through the integration of genetic, biologic, and engineering tools. Genetics permits the detection and regional mapping of genes involed in disease processes. Concurrently, we are gathering detailed molecular and proteomic data about the biological variation. These studies will provide valuable insights into the mechanisms of disease susceptibility or phenotpic variation and will help in the identification of causitive genes. Lastly, we are also using established genetic engineering techniques and experimenting with new methods for the validation of candidate genes.  Our long-term goal is predictive medicine, which will allow for more informed targeted screening for diseases and pre-emptive treatments to prevent them from becoming life threatening.
 How to find us We are located in the Lineberger Comprehensive Cancer Center in the center of the UNC medical school quadrangle. Our labs are on the first floor in rooms 11-109, 11-110, and 11-111. You can reach us at 919-843-6470 or -6471. A pdf campus map can be found here. |
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