David Threadgill, PhD
University Distinguished Professor
Tom and Jean McMullin Chair of Genetics
Director, Texas A&M Institute for Genome Sciences and Society
Department of Veterinary Pathobiology
​Department of Molecular and Cellular Medicine
BS Zoology, Texas A&M University
PhD Genetics, Texas A&M University
Postdoc, Case Western Reserve University

Faculty

Rachel Lynch, PhD
Lecturer
BS Biology, Cedarville University
PhD Genome Science & Technology, University of Tennessee

Professional Staff

Ritika Chaubey
Research Assistant
BS Genetics, Texas A&M University
Mouse colony guru

Lauren Farris
Research Assistant
BS Bioenvironmental Sciences, Texas A&M University
Lab Manager and cell culture czarina

Graduate Students

Selene Howe
Genetics
​BS Molecular Genetics, University of Rochester
Cancer chemoprevention
​

Amie Perry, DVM
Veterinary Pathobiology
BS Biology, University of Montebello
​DVM, Auburn University
TCE-induced kidney toxicity

Shante Bryant
Genetics
BS Biochemistry, NC State University
Genetics of IBS

Melanie Warren
Toxicology
​BS Biology, Louisana State University
Dioxin cardiotoxicity​
​
​

Julia Popp
Veterinary Pathobiology
BS Biology, Augustana College
​iPS-based cardiotoxicity testing
​

Kristin Scoggin
Genetics
BS Biochemistry, TCU
TBD

Dona Kanavy
Genetics
BS Clinical Laboratory Science, University of North Carolina
Genetic pest control​

Carolina Mantilla Rojas
Genetics
BS Biology, Universidad Nacional de Columbia
EGFR independent colon cancer
​

Anna Salvador
Nutrition
BS Nutrition and Food Science, McNeese State University
Diet and health
Visiting Students
Crystol Blair
​University of Surrey (UK)
​Undergraduate Student Intern
Laura Deus
​University of Surrey (UK)
​Undergraduate Student Intern
Edeline D'Souza
University of Surrey (UK)
​Undergraduate Student Intern
Danila Cuomo
​Università del Sannio (Italy)
PhD Student

Undergraduate Research Teams

Team PC"R"US
​Leader: Lauren Farris
​Jessica Lee
Pedro Gonzalez
Andrew Klopfer
Annie Nguyen
​Alison Zill
Team Chubby Chasers
Leader: Bill Barrington
Ahmed Elsaadi
​Avery Valls
Team Poke & Scope
Leader: Carolina Mantila
Jorge James
​Sydney Schuetze
Marien Lara
​Kathryn Anderson
Team #2
Leader: Bill Barrington
Anthony Gacasan
David Thronberg
Lora Moore
Team Almost Solitaire
Leader: Suzette Palmer
​Shivani Chandramohan
Team Mini Mouse Mappers
Leader: Amanda Lanier
​Rachel Smith
​Hannah Otiker
Team TIGGS
Leader: Drew Hillhouse
​David Thronberg
​Kevin Tracy
Team HeMan
Leader: Dona Kanavy
Jace Aloway
Taylor Reavis
Morgan Ziemer
Team Heartbreaker
Leader: Melanie Warren
Kalia Brooks
​Diana Bueso-Mendoza
Amy Cooper
Malynn Ilanga
Megan Nitcher
Shelby Zumwalt
Ashlyn Kinard
Delanie Moses
Francis Mtuke
​Ali Bodovsky
Team Transformers
Leader: Rachel Lynch
Jacqueline Macias
Ana Suarez
Kishan Patel
​Chris Chen
Team Baymax
Leader: Selene Howe
Justin Dam
Jared Eichner
Elliot Flint
Nataly Gomez
Breanna Loberger
Carolyn McCrossan
Bethany Smith
Rachel Thomas
Ashtyn Zapletal

Former Lab Members

Postdocs
  • Scott Persall PhD (1998-2000); Senior Director of Cell Biology and Protein Chemistry, Acceleron Pharmaceuticals
          - McQuain M, Duncavage EJ, Pearsall RS, Threadgill DW, Coffey RJ, Haselton F. 1999. Quantitative comparison of protocols for DNA attachment and hybridization to glass. Annals of Biomedical Engineering 1:S124.
          - Chaurand P, Dague BB, Pearsall RS, Threadgill DW, Caprioli RM. 2001. Profiling proteins from azoxymethane-induced colon tumors at the molecular level by MALDI mass spectrometry. Proteomics 1:1320-1326.
​          - Reiter JL, Threadgill DW, Eley GD, Strunk KE, Danielsen AJ, Schell-Sinclair C, Pearsall RS, Green PJ, Yee D, Lampland AL, Balasubramaniam S, Crossley TO, Magnuson TR, James CD, Maihle NJ. 2001. Comparative genomic sequence analysis and isolation of human and mouse alternative Egfr transcripts encoding truncated receptor isoforms. Genomics 71:1-20.
​          - Lee D, Pearsall RS, Das S, Dey SK, Godfrey VL, Threadgill DW. 2004. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Molecular and Cellular Biology 24:8907-8916.
​          - Bissahoyo A, Pearsall RS, Hanlon KE, Amann V, Hicks D, Godfrey VL, Threadgill DW. 2005. Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet. Toxicological Sciences 88:340-345.
​          - Franklin JL, Yoshiura K, Dempsey PJ, Bogatcheva G, Jeyakumar L, Meise S, Pearsall RS, Threadgill DW, Coffey RJ. 2005. Identification of MAGI-3 as a transforming growth factor-a binding protein. Experimental Cell Research 303:457-470.
​          - Eversley CD, Xie Y, Pearsall RS, Threadgill DW. 2012. Mapping six new Susceptibility to Colon Cancer (Scc) loci using a mouse inter-specific backcross. G3: Genes, Genomes and Genetics 2:1577-1584.
  • Daekee Lee PhD (1998-2005); Associate Professor, Ewha Womens University
​          - Fitch KR, McGowan KA, van Raamsdonk CD, Fuchs H, Lee D, Puech A, Herault Y, Threadgill DW, Hrabe de Angelis M, Barsh GS. 2003. Genetics of dark skin in mice. Genes and Development 17:214-28.
​          - Lee D, Threadgill DW. 2004. Investigating gene function using mouse models. Current Opinion in Genetics and Development 14:246-252.
​          - Lee D, Cross SH, Strunk KE, Morgan JE, Bailey CL, Jackson IJ, Threadgill DW. 2004. Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mammalian Genome 15:525-536 (Cover Figure).
​          - Lee D, Pearsall RS, Das S, Dey SK, Godfrey VL, Threadgill DW. 2004. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Molecular and Cellular Biology 24:8907-8916.
​          - Genther Williams SM, Disbrow G, Schlegel R, Lee D, Threadgill DW, Lambert PF. 2005. Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high risk human papillomavirus oncogene. Cancer Research: 65:6534-6542.
​          - Hsieh M, Lee D, Panigone S, Horner K, Chen R, Lee DC, Threadgill DW, Conti M. 2007. LH-dependent activation of the EGF network is essential for ovulation. Molecular and Cellular Biology 27:1914-1924.
          ​​- Lee DK, Yu M, Lee E, Kim H, Yang Y, Paniccia C, Kim K, Kurie JM, Threadgill DW. 2009. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in the intestinal epithelium. Journal Clinical Investigation 119:2702-2713.
          ​​- Moy SS, Ghashghaei HT, Nonneman RJ, Weimer JM, Yokota Y, Lee D, Lai C, Threadgill DW, Anton ES. 2009. Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophrenia. Journal of Neurodevelopmental Disorders 1:302-312.
          ​​- Ceddia RP, Lee DK, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuiness OP, Gannon M, Breyer RM. 2016. The PGE2 EP3 receptor regulates diet-induced adiposity in male mice. Endocrinology 157:220-232.
  • Deloris Alexander PhD (2001-2005); Director of Integrative Biosciences PhD Program, Tuskegee University
​          - Alexander AD, Orcutt RP, Henry JC, Baker J, Bissahoyo AC, Threadgill DW. 2006. Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment. Mammalian Genome 17:1093-1104.
  • Haider Ali Syed Phd (2003-2009); Research Associate, North Carolina Center University
​          - Syed HA, Threadgill DW. 2006. Enhanced oligonucleotide microarray labeling and hybridization. BioTechniques 41:685-686.
​          - Munger SC, Aylor DL, Syed HA, Magwene PM, Threadgill DW, Capel B. 2009. Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. Genes and Development 23:2521-2536.
  • Elyse Lee PhD (2006-2009); Scientific Program Associate, International Life Sciences Institute Research Foundation
  • Christine Powell PhD (2007-2014), NIH Postdoctoral National Research Service Award; Senior Scientific Communications Manager, Translational Genomics Research Institute
​          - Powell CL, Bradford BU, Craig CP, Tsuchiya M, Uehara T, O-Connell TM, Pogribny IP, Melnyk S, Koop DR, Bleyle L, Threadgill DW, Rusyn I. 2010. Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicological Sciences 115:131-139.
​          - Aylor  DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Calaway JD, Didion JD, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SNP, Collins F, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill DW, de Villena FP-M, Churchill GA. 2011. Genetic analysis of complex traits in the emerging collaborative cross. Genome Research 21:1213-1222.
  • David Bautz PhD (2009-2014), NIH Postdoctoral National Research Service Award; Associate Biotech Analyst, Zacks Investment Research
​          - Bautz DJ, Broman KW, Threadgill DW. 2013. Identification of a novel polymorphism in X-linked sterol-4-alpha-carboxylate 3-dehydrogenase (Nsdhl) associated with reduced HDL cholesterol levels in I/LnJ mice. G3: Genes, Genomes and Genetics 3:1819-1825. 
  • Ryan Gordon PhD (2009-2010), Assistant Professor, Oregon Health & Science University
  • Andrew Hillhouse PhD (2010-2015), Assistant Professor, Texas A&M University
​          - Donohoe DR, Holley D, Collins LB, Montgomery SA, Whitmore AC, Hillhouse A, Curry KP, Renner SW, Tillotson C, Ryan EP, Godfrey V, Heise MT, Threadgill DS, Swenberg JA, Threadgill DW, Bultman SJ. 2014. A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner. Cancer Discovery 4:1387-1397.

Graduate Students
  • Karen Strunk PhD (Cell Biology, Vanderbilt University, 2002), “Genetic background modifiers of the epidermal growth factor receptor null phenotype”; Instructor, Central New Mexico Community College
​          - Reiter JL, Threadgill DW, Eley GD, Strunk KE, Danielsen AJ, Schell-Sinclair C, Pearsall RS, Green PJ, Yee D, Lampland AL, Balasubramaniam S, Crossley TO, Magnuson TR, James CD, Maihle NJ. 2001. Comparative genomic sequence analysis and isolation of human and mouse alternative Egfr transcripts encoding truncated receptor isoforms. Genomics 71:1-20.
​          - Strunk K, Amann V, Threadgill DW. 2004. Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be molecularly partitioned. Genetics 167:1821-1832.
​          - Lee D, Cross SH, Strunk KE, Morgan JE, Bailey CL, Jackson IJ, Threadgill DW. 2004. Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mammalian Genome 15:525-536 (Cover Figure).
          - Dackor J, Strunk KE, Wehmeyer MM, Threadgill DW. 2007. Altered trophoblast proliferation is insufficient to cause placental dysfunction in Egfr null embryos. Placenta 28:1211-1218.
  • Reade Roberts PhD (Cell Biology, Vanderbilt University, 2003), “Modeling the consequences of epidermal growth factor receptor inhibition in vivo using the classical Egfrwa2 mutant mouse”; Assistant Professor, North Carolina State University
          - Roberts RB, Min L, Washington MK, Olsen SJ, Settle SH, Coffey RJ, Threadgill DW. 2002. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci USA 99:1521-1526.
          - Roberts RB, Arteaga CL, Threadgill DW. 2004. Modeling the entire patient: predicting side-effects of targeted therapies with the genetically engineered mouse. Cancer Cell 5:115-120.
          - Mrosovsky N, Redlin U, Roberts RB, Threadgill DW. 2005. Masking in Waved-2 mice: lack of evidence for EGF receptor control of locomotion. Chronobiology International 22:963-974.
          - Roberts RB, Threadgill DW. 2005. ‘The mouse in biomedical research’ in Eisen EJ (ed), The Mouse in Animal Genetics and Breeding Research, Imperial College Press, London.
          - Roberts RB, Thompson CL, Lee D, Mankinen RW, Sancar A, Threadgill DW. 2006. Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice. Journal Circadian Rhythms 4:15-20.
          - Kaiser S, Park Y, Franklin J, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga A, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Roberts RB, Bissahoyo AC, Gonzales F, Bloom G, Eschrich S, Carter SL, Aronow J, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden JM, Dove WF, Threadgill DW, Yeatman T, Coffey RJ, Aronow BJ. 2007. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biology 8:R131.1-R131.26.
          ​​- Barrick CJ, Roberts RB, Rojas M, Rajamannan NM, Suitt CB, O’Brien KD, Smyth SS, Threadgill DW. 2009. Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. American Journal of Physiology-Heart and Circulation 297:H65-75.
  • Anika Bissahoyo PhD (Toxicology, University of North Carolina, 2005), “Pathobiology of strain-specific responses to azoxymethane-induced colorectal cancer”, NIH Predoctoral National Research Service Award; Director of Research and Sponsored Programs, Bowie State University
​​          ​- Bissahoyo A, Pearsall RS, Hanlon KE, Amann V, Hicks D, Godfrey VL, Threadgill DW. 2005. Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet. Toxicological Sciences 88:340-345.
​          ​- Alexander AD, Orcutt RP, Henry JC, Baker J, Bissahoyo AC, Threadgill DW. 2006. Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment. Mammalian Genome 17:1093-1104.
          ​- Uronis JM, Herfarth HH, Rubinas TC, Bissahoyo AC, Hanlon K, Threadgill DW. 2007. Flat colorectal cancers are genetically determined and progress to invasive cancer without going through a polypoid stage. Cancer Research 67:11594-11600 (Cover Figure).
          - ​Kaiser S, Park Y, Franklin J, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga A, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Roberts RB, Bissahoyo AC, Gonzales F, Bloom G, Eschrich S, Carter SL, Aronow J, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden JM, Dove WF, Threadgill DW, Yeatman T, Coffey RJ, Aronow BJ. 2007. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biology 8:R131.1-R131.26.
          ​- Chi Y-Y, Ibrahim JG, Bissahoyo AC, Threadgill DW. 2007. Baysian hierarchical modeling for time course microarray experiments. Biometrics 63:496-504.
  • Tang-Cheng Lee PhD (Genetics, University of North Carolina, 2007), “Functional analysis of EGFR using a conditional allele”; Research Fellow, Baylor College of Medicine
          ​- Lee TC, Threadgill DW. 2009. Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor. Genesis 47:85-92.
          ​- ​Maklad A, Nicolai JR, Bischel KJ, Evenson JE, Lee TC, Threadgill DW, Hansen LA. 2009. The EGFR is required for proper innervation to the skin. Journal of Investigative Dermatology 129:690-698.
          ​- ​Zhang Z, Pascuet E, Hueber PA, Chu L, Bichet DG, Lee TC, Threadgill DW, Goodyer P. 2010. Targeted inactivation of EGF receptor inhibits renal collecting duct development and function. Journal American Society of Nephrology 21:573-578.
          ​- ​Mascia F, Cataisson C, Lee TC, Threadgill DW, Mariani V, Amerio P, Chandrasekhara C, Souto Adeva G, Girolomoni G, Yuspa SH, Pastore S. 2010. EGFR regulates the expression of keratinocyte derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo. Journal of Investigative Dermatology 130:682-693.
          ​- ​Zhang X, Tamasi J, Lu X, Zhu J, Chen H, Tian X, Lee TC, Threadgill DW, Kream BE, Kang Y, Partridge NC, Qin L. 2011. Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo. Journal of Bone Mineral Research 26:1022-1034.
          ​- ​Chen J, Chen JK, Nagai K, Plieth D, Tan M, Lee TC, Threadgill DW, Neilson EG, Harris RC. 2012. EGFR signaling promotes TGFβ-dependent renal fibrosis. Journal of the American Society of Nephrology 23:215-224.
  • Delia Barrick PhD (Toxicology, University of North Carolina, 2007), “Modeling the consequences of epidermal growth factor receptor inhibition on cardiac development, function and homeostasis”; Project Manager, University of North Carolina
          ​- Barrick CJ, Rojas M, Schoonhoven R, Smyth SS, Threadgill DW. 2007. Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal and background dependent development of concentric left ventricular hypertrophy. American Journal Physiology-Heart and Circulation 292:2119-2130.
          - ​Barrick CJ, Yu M, Chao H-H, Threadgill DW. 2008. Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice. Toxicology and Applied Pharmacolgy 228:315-325.
          ​- Barrick CJ, Dong A, Waikel R, Corn D, Yang F, Threadgill DW, Smyth SS. 2009. Parent-of-origin effects on cardiac response to pressure overload in mice. American Journal of Physiology-Heart and Circulation 297:H1003-1009.
          ​- Barrick CJ, Roberts RB, Rojas M, Rajamannan NM, Suitt CB, O’Brien KD, Smyth SS, Threadgill DW. 2009. Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. American Journal of Physiology-Heart and Circulation 297:H65-75.
​          - ​Crowley JJ, Zhabotynsky V, Sun W, Huang S, Pakatci IK, Kim Y, Wang JR, Morgan AP, Calaway JD, Aylor DL, Yun Z, Bell TA, Buus RJ, Calaway ME, Didion JP, Gooch TJ, Hansen SD, Robinson NN, Shaw GD, Spence JS, Quackenbush CR, Barrick CJ, Nonneman RJ, Kim K, Xenakis J, Xie Y, Valdar W, Lenarcic AB, Wang W, Welsh CE, Fu CP, Zhang Z, Holt J, Guo Z, Threadgill DW, Tarantino LM, Miller DR, Zou F, McMillan L, Sullivan PF, Pardo-Manuel de Villena F. 2015. Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance. Nature Genetics 47:353-360.
  • Ming Yu PhD (Oral Biology, University of North Carolina, 2007), "The importance of ERBB receptor tyrosine kinase signaling in colorectal cancer: implications for EGFR-targeted therapies”; Research Fellow, Fred Hutchinson Cancer Research Center
          ​- Kaiser S, Park Y, Franklin J, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga A, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Roberts RB, Bissahoyo AC, Gonzales F, Bloom G, Eschrich S, Carter SL, Aronow J, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden JM, Dove WF, Threadgill DW, Yeatman T, Coffey RJ, Aronow BJ. 2007. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biology 8:R131.1-R131.26.
          ​​- Barrick CJ, Yu M, Chao H-H, Threadgill DW. 2008. Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice. Toxicology and Applied Pharmacolgy 228:315-325.
          ​​- Lee DK, Yu M, Lee E, Kim H, Yang Y, Paniccia C, Kim K, Kurie JM, Threadgill DW. 2009. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in the intestinal epithelium. Journal Clinical Investigation 119:2702-2713.
  • Jennifer Dackor PhD (Genetics, University of North Carolina, 2008), “Use of an allelic series in mice to study the role of epidermal growth factor receptor in placental development and pregnancy”; Business Development Manager, Roots Hummus
          - Fujimoto H, Wislez M, Zhang J, Iwanaga K, Dackor J, Hanna AE, Kalyankrishna S, Cody DD, Price RE, Sato M, Shay JW, Minna JD, Peyton M, Tang X, Massarelli E, Herbst R, Threadgill DW, Wistuba I, Kurie JM. 2005. High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Research 65:11478-11485.
          - Dackor J, Strunk KE, Wehmeyer MM, Threadgill DW. 2007. Altered trophoblast proliferation is insufficient to cause placental dysfunction in Egfr null embryos. Placenta 28:1211-1218.
          - Dackor J, Caron KM, Threadgill DW. 2009. Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles. Genetics 183:207-218.
          - Dackor J, Li M, Threadgill DW. 2009. Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor. Mammalian Genome 20:339-349 (Cover Figure).
  • Josh Uronis PhD (Genetics, University of North Carolina, 2008), “Histological and molecular analysis of colorectal cancer morphology”; Clinical Development Scientist, GeneCentric Diagnostics​
          - Uronis JM, Herfarth HH, Rubinas TC, Bissahoyo AC, Hanlon K, Threadgill DW. 2007. Flat colorectal cancers are genetically determined and progress to invasive cancer without going through a polypoid stage. Cancer Research 67:11594-11600 (Cover Figure).
          - Uronis JM, Threadgill DW. 2009. Murine models of colorectal cancer. Mammalian Genome 20:261-268 (Cover Figure).
          - Pysz MA, Leontieva OV, Bateman NW, Uronis JM, Curry KJ, Threadgill DW, Janssen KP, Robine S, Velcich A, Augenlicht L, Black AR, Black JD. 2009. PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Experimental Cell Research 315:1415-1428.
  • Erica Rinella PhD (Genetics, University of North Carolina, 2008), “Impact of diet on EGFR-targeted treatment of colorectal cancer”, NIH Predoctoral National Research Service Award; Review Analyst, BioReference Laboratories
          - Rinella ES, Eversley C, Carroll IM, Andrus JM, Threadgill DW, Threadgill DS. 2006. Human epithelia-specific response to pathogenic Campylobacter jejuni. FEMS Microbioogy Letters 262:236-243.
          - Radiloff D, Rinella E, Threadgill DW. 2008. Modeling cancer patient populations in mice: complex genetics and environmental factors. Drug Discovery Today: Disease Models 4:83-88.
          - Rinella ES, Threadgill DW. 2012. Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials. PLoS ONE 7:e39552.
          - Rinella ES, Bankaitis ED, Threadgill DW. 2012. Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer. Cancer Biology and Therapy 13:130-137.
  • Michelle LaMerrill PhD (Toxicology, University of North Carolina, 2008), “Influence of diet and maternal dioxin on endocrine disruption: puberty, metabolic syndrome, and breast cancer”, DOD Breast Cancer Predoctoral Research Fellowship; Assistant Professor, University of California-Davis
          - Gordon R, Hunter KW, LaMerrill M, Threadgill DW, Pomp D. 2008. Genotype X diet interactions in mice predisposed to mammary cancer: II. tumors and metastasis. Mammalian Genome 19:179-189.
          - LaMerrill MA, Kurvilla BS, Pomp D, Birnbaum LS, Threadgill DW. 2009. Dietary fat alters body composition, mammary development and P450 induction following maternal TCDD exposure in DBA/2J mice that express low responsive aryl hydrocarbon receptors. Environmental Health Perspectives 117:1414-1419.
          - LaMerrill M, Baston DS, Denison MS, Birnbaum LS, Pomp D, Threadgill DW. 2009. Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. Am J Physiol-Endocrinology and Metabolism 296:E203-210.
          - Gordon RR, LaMerrill MA, Hunter KW, Sorensen P, Threadgill DW, Pomp D. 2010. Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis. Clinical and Experimental Metastasis 27:279-293.
          - LaMerrill MA, Harper R, Birnbaum LS, Cardiff RD, Threadgill DW. 2010. Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence. Environmental Health Perspectives 118:596-601.
          - LaMerrill MA, Gordon RR, Hunter KW, Threadgill DW, Pomp D. 2010. Dietary fat alters pulmonary metastasis of mammary cancers through cancer autonomous and non-autonomous changes in gene expression. Clinical and Experimental Metastasis 27:107-116.
  • Chevonne Eversley PhD (Genetics, University of North Carolina, 2009), “Genetic and molecular analysis of colorectal cancer susceptibility”, NIH Predoctoral National Research Service Award; Associate Technical Director, LabCorp
          ​- Rinella ES, Eversley C, Carroll IM, Andrus JM, Threadgill DW, Threadgill DS. 2006. Human epithelia-specific response to pathogenic Campylobacter jejuni. FEMS Microbioogy Letters 262:236-243.
          ​- Huang H, Eversley CD, Threadgill DW, Zou F. 2007. Bayesian multiple quantitative trait loci mapping for complex traits using markers of the entire genome. Genetics 176:2529-2540.
          ​- Eversley CD, Clark T, Xie Y, Steigerwalt J, Bell TA, de Villena FP, Threadgill DW. 2010. Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross. BMC Genetics 11:98-103.
​          - ​Eversley CD, Xie Y, Pearsall RS, Threadgill DW. 2012. Mapping six new Susceptibility to Colon Cancer (Scc) loci using a mouse inter-specific backcross. G3: Genes, Genomes and Genetics 2:1577-1584.
  • Melanie Weed PhD (Toxicology, University of North Carolina, 2010), “The impact of epidermal growth factor receptor inhibition on energy homeostasis”; Toxicologist, U.S. Consumer Product Safety Commission
  • Michelle DeSimone PhD (Toxicology, University of North Carolina, 2010), “In vitro and in vivo models to assess kidney toxicity of environmental carcinogens”, SOT Syngenta Fellowship Award in Human Health Applications of New Technologies; Translational Science Fellow, Roche
          ​- Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T,  Harbourt D, DeSimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I. 2011. Inter-strain differences in the liver effects of trichloroethylene in a multi-strain panel of inbred mice. Toxicological Sciences 120: 206-217.
          ​- DeSimone MC, Rathmell WK, Threadgill DW. 2013. Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis and ATM-mediated DNA damage response. Journal of the National Cancer Institute 105:1355-1364.
  • Yuying Xie PhD (Genetics, University of North Carolina, 2012), “Role of epidermal growth factor receptor on cardiac function”; Assistant Professor, Michigan State University
          ​- Eversley CD, Clark T, Xie Y, Steigerwalt J, Bell TA, de Villena FP, Threadgill DW. 2010. Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross. BMC Genetics 11:98-103.
​        - Aylor  DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Calaway JD, Didion JD, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SNP, Collins F, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill DW, de Villena FP-M, Churchill GA. 2011. Genetic analysis of complex traits in the emerging collaborative cross. Genome Research 21:1213-1222.
​          - ​Eversley CD, Xie Y, Pearsall RS, Threadgill DW. 2012. Mapping six new Susceptibility to Colon Cancer (Scc) loci using a mouse inter-specific backcross. G3: Genes, Genomes and Genetics 2:1577-1584.
​          - ​Phillippi J, Xie Y, Miller DR, Bell TA, Zhang Z, Lenarcic AB, Aylor DL, Krovi SH, Threadgill DW, Pardo-Manuel de Villena F, Wang W, Valdar W, Frelinger JA. 2014. Using the emerging Collaborative Cross to probe the immune system. Genes and Immunity 15:38-46.
​          - ​Crowley JJ, Zhabotynsky V, Sun W, Huang S, Pakatci IK, Kim Y, Wang JR, Morgan AP, Calaway JD, Aylor DL, Yun Z, Bell TA, Buus RJ, Calaway ME, Didion JP, Gooch TJ, Hansen SD, Robinson NN, Shaw GD, Spence JS, Quackenbush CR, Barrick CJ, Nonneman RJ, Kim K, Xenakis J, Xie Y, Valdar W, Lenarcic AB, Wang W, Welsh CE, Fu CP, Zhang Z, Holt J, Guo Z, Threadgill DW, Tarantino LM, Miller DR, Zou F, McMillan L, Sullivan PF, Pardo-Manuel de Villena F. 2015. Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance. Nature Genetics 47:353-360.
  • William Barrington PhD (Genetics, North Carolina State University, 2016), "Individual variation in diet response: health effects of dietary interventions on mice with diverse genetic backgrounds"; Postdoctoral Scholar, UCLA
  • Tiffany Garbutt PhD (Genetics, North Carolina State University, 2017), 

​Undergraduate Students
  • Vicky Wilkinson (Cambridge University, UK), Women in Science Vanderbilt Summer Undergraduate Program, 1997
  • Allison Truell (Biology, Vanderbilt), 1997-1998
  • Amy Williams (Biology, Vanderbilt), 1998-2000
  • Tara Thompson (Biology, Vanderbilt), 1999-2000
  • Josh Parnum (Biology, Vanderbilt), 1999-2000
  • Robert Boykin (Biology, UNC), 2000-2002, Biology Honors “Mouse strain-dependent differences in gastrointestinal morphology”
          - Boykin R, Threadgill DW. 2002. Genetics definitions in: Child Development, Vol One in the Macmillan Psychology Reference Series.
  • Ben Wood (Biology, UNC), 2000-2003, Biology Honors “Analysis of a carcinogen-based mouse model for hepatocarcinogenesis”
  • Meggan (Hovick) Wehmeyer (Biology, UNC), 2001-2003, Biology Honors “Molecular and histological characterization of murine epidermal growth factor receptor null placentae”, Winner of the 2003 Department of Biology H.V.P. Wilson Award for excellence in research in cellular and molecular biology
          - Dackor J, Strunk KE, Wehmeyer MM, Threadgill DW. 2007. Altered trophoblast proliferation is insufficient to cause placental dysfunction in Egfr null embryos. Placenta 28:1211-1218.
  • Elisabeth Greer (University of Virginia), 2002 UNC SURE Summer Program
  • Hal Wray (Biology, UNC), 2001-2002
  • Candice Bailey (Chemistry, UNC), 2001-2003, Chemistry Honors “Biochemical analysis of the receptor encoded by the Wa5 mutation in Egfr”
          - Lee D, Cross SH, Strunk KE, Morgan JE, Bailey CL, Jackson IJ, Threadgill DW. 2004. Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mammalian Genome 15:525-536 (Cover Figure).
  • Rusty Mankinen (Biology, UNC), 2002-2003, Biology Honors “Phenotypic analysis of the epidermal growth factor receptor mutation waved-2 on inbred genetic backgrounds”
          ​- Roberts RB, Thompson CL, Lee D, Mankinen RW, Sancar A, Threadgill DW. 2006. Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice. Journal Circadian Rhythms 4:15-20.
  • Michael Haughton (Willamette University), 2003 UNC SURE Summer Program
  • Lori Leslie (Chemistry, UNC), 2004-2005, Chemistry Honors (Highest) “Induction of mitotic recombination for in vitro genetics”
  • Meera Shah (Biology, UNC), 2003-2005
  • Sha Syed (Chemistry, UNC), 2003-2004
  • Liz Clore (Psychology, UNC), 2003-2005
  • JaNell Henry (Biology, UNC), 2004-2006
​          ​- Alexander AD, Orcutt RP, Henry JC, Baker J, Bissahoyo AC, Threadgill DW. 2006. Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment. Mammalian Genome 17:1093-1104.
  • Natalie Hodges (Biology, UNC), 2003-2006
  • Katie Hanlon (Biology, UNC), 2004-2006, Recipient of a 2005-2006 AACR-Thomas J. Bardos Science Education Award
​          ​- Bissahoyo A, Pearsall RS, Hanlon KE, Amann V, Hicks D, Godfrey VL, Threadgill DW. 2005. Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet. Toxicological Sciences 88:340-345.
          ​- Uronis JM, Herfarth HH, Rubinas TC, Bissahoyo AC, Hanlon K, Threadgill DW. 2007. Flat colorectal cancers are genetically determined and progress to invasive cancer without going through a polypoid stage. Cancer Research 67:11594-11600 (Cover Figure).
  • Lindsay McConnell (Biology, UNC), 2004-2005
  • Carla Martin (Chemistry, UNC), 2004-2005
  • Christina Paniccia (Biology, UNC), 2004-2006, Recipient of a 2005-2006 AACR-Thomas J. Bardos Science Education Award
          ​​- Lee DK, Yu M, Lee E, Kim H, Yang Y, Paniccia C, Kim K, Kurie JM, Threadgill DW. 2009. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in the intestinal epithelium. Journal Clinical Investigation 119:2702-2713.
  • Holly Love (Biology, UNC), 2005-2006
  • Jessica Heinz (Biology, UNC), 2005-2006
  • Joi Weeks (Chemistry, UNC), 2005-2006
  • Bittu Kurvilla (Chemistry, UNC), 2005-2006, Chemistry Honors: “Effects of aromatic hydrocarbons on mammary gland cancer”
          - LaMerrill MA, Kurvilla BS, Pomp D, Birnbaum LS, Threadgill DW. 2009. Dietary fat alters body composition, mammary development and P450 induction following maternal TCDD exposure in DBA/2J mice that express low responsive aryl hydrocarbon receptors. Environmental Health Perspectives 117:1414-1419.
  • Eric Bankaitis (Biology, UNC), 2005-2006, Biology Honors “The combined effects of dietary supplementation and molecular-targeted therapy on colon cancer cell proliferation in vitro”
          - ​Rinella ES, Bankaitis ED, Threadgill DW. 2012. Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer. Cancer Biology and Therapy 13:130-137.
  • Aline Alexanian (Biology, UNC), 2005-2006
  • Adam Corn (Biology, UNC), 2005-2007
  • Dawn Hrelic (Biology, UNC), 2006-2007
  • Anne Dvorak (Biology, UNC), 2006-2007
  • Drew Corn (Biology, UNC), 2006-2007
  • Richard Frye (Biology, UNC), 2006-2008, Biology Honors “Characterization of epidermal growth factor receptor independent colorectal tumors in the ApcMin mouse model”
  • Patrick Summers (Biology, UNC), 2007-2008
  • Jennifer Zeng (Biology, UNC), 2007-2008
  • Brent Chen (Biology, UNC), 2007-2008
  • Tavia Clark (Biology, UNC), 2007-2008
          ​- Eversley CD, Clark T, Xie Y, Steigerwalt J, Bell TA, de Villena FP, Threadgill DW. 2010. Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross. BMC Genetics 11:98-103.
  • Rachel Harper (Biology, UNC), 2007-2009, Biology Honors (Highest) and selected presenter for the 9th Annual UNC Celebration of Undergraduate Research “Dietary fat and dioxin exposure increase mammary cancer incidence through Cyp1b1 and Comt expression”
          - ​LaMerrill MA, Harper R, Birnbaum LS, Cardiff RD, Threadgill DW. 2010. Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence. Environmental Health Perspectives 118:596-601.
  • Angela Kashap (Biology, NCSU), 2009-2010, CALS Honors “Pre-clinical detection of risk factors for idiosyncratic drug-induced liver injury”
  • Everett Warren (Biochemistry, NCSU), 2009-2010, CALS Honors “A comparative study of blastocyst implantation in three strains of mice: C3H, 129, and B6”
  • Ben Rusche (Microbiology, NCSU), 2009-2010
  • Katie Caviness (Animal Science, NCSU), 2009-2010
  • Becky Brulet (Zoology, NCSU), 2010-2011
  • Tara Buff (Biology, NCSU), 2010-2011
  • Kimberly Wagner (Biochemistry, NCSU), 2010-2011
  • Garrison Glavich (Microbiology, NCSU), 2010-2011
  • Megan Morse (Nutrition, NCSU), 2010-2012, CALS Honors “Correlation between genotype and mouse limb length”
  • Alan Bohn (Microbiology, NCSU), 2010-2012
  • Keiko Wadsworth (Microbiology, NCSU), 2010-2013, CALS Honors “Environmental carcinogen-induced retinal degeneration in a population-based mouse model”
  • Anna Knight (Biology, NCSU), 2010-2013, CALS Honors “Comparison of Apc and beta-catenin mouse models for colorectal cancer”
  • Kritika Joshi (Biology, NCSU), 2011, CALS Honors “Modeling Parkinson’s Disease in mice with trichloroethylene and inorganic arsenic”
  • Madison Pace (Biology, NCSU), 2011
  • Amanda Gross (Animal Science, NCSU), 2011-2012
  • Molly Matty (Chemistry, NCSU), 2011-2012, Recipient of an NSF Predoctoral Research Fellowship as a senior, NCSU Honors “Development of an assay to determine telomere length using real time PCR of Mus musculus embryonic fibroblasts as compared to a single copy gene, epidermal growth factor receptor”
  • Kara Peterson (Biology, NCSU), 2011-2012
  • Hanna Gardner (Animal Science, NCSU), 2011-2012
  • Emma Friberg (Biology NCSU), 2011-2012, CALS Honors “Modeling human diseases in mice: effects of trichloroethylene and inorganic arsenic”
  • Ang Sherpa (University of Surrey, UK), Internship, 2011-2012
  • Lindsay Speir (Biology, NCSU), 2011-2012
  • Hope Hendricks (Biology, NCSU), 2011-2013
  • Victoria Ramos (Biology, NCSU), 2011-2013
  • Jennifer Baker (Biology, NCSU), 2012
  • Michael Yarboro (Biology, NCSU), 2012-2013, CALS Honors “ Effect of diet on cardiac health parameters”
  • Kate Owens (Chemistry, NCSU), 2012-2013
  • Jasper Schulte (Humboldt-Universität zu Berlin, Germany), Internship, 2012-2013
  • Haley Crockett (University of Surrey, UK), Internship exchange, 2012-2013
  • Kelsey Parrish (Biology, NCSU), 2012-2013
  • Courtney Vaughn (Biology, NCSU), 2012-2013
  • Joshua Quinn (Biology, NCSU), 2012-2013
  • Morgan McCafferty (Animal Science NCSU), 2012-2013
  • Jennifer Gredler (Biology, NCSU), 2012-2013
  • Brittany Tolomeo (Zoology, TAMU), 2014-2015
  • Aaron Van Wettering (Microbiology, TAMU), 2014-2016
  • Ephraim Yusi (University of Surrey, UK), Internship exchange, 2015-2016
  • Andreea Radulescu (University of Surrey, UK), Internship exchange, 2015-2016
  • Laura Schulze (West Texas A&M University), VMSTR Program, 2016
  • CidNi Wilkerson (Prairie View A&M University), TAMHSC SRP, 2016
  • Sanjana Srikanth (Health, TAMU), 2016
  • Alyssa Schaeffer (Computer Science, TAMU), 2016
  • Gentrea Hendrickson (Microbiology, TAMU), 2016
  • Yusra Aziz (Genetics, TAMU), 2016
  • Xavier Balboa (Biomedical Science, TAMU), 2016
  • Koren Dunn (Biomedical Science, TAMU), 2016
  • Madison Martock (Biomedical Sciences, TAMU), 2016
  • Amber Smith (Biomedical Sciences, TAMU), 2016
  • Ashley Harrison (Biology, TAMU), 2016
  • Stephanie Mundahl (Biomedical Sciences, TAMU), 2016
  • Kylie Petty (Nutritional Sciences, TAMU), 2016
  • Marc Gohel (Biology, TAMU), 2016
  • Elizabeth Li (Biochemistry, TAMU), 2016
  • Eva Trevino (Biomedical Sciences, TAMU), 2016