Didion JP, Morgan AP, Yadgary L, Bell TA, McMullan RC, de Solorzano LO, Britton-Davidian J, Bult CJ, Campbell KJ, Castiglia R, Ching YH, Chunco AJ, Crowley JJ, Chesler EJ, French JF, Gabriel SI, Gatti DM, Garland T, Giagia-Athanasopoulou EB, Giménez MD, Grize S, Gündüz I, Holmes A, Hauffe HC, Herman JS, Holt JM, Hua K, Jolley WJ, Lindholm A, López-Fuster MJ, Mitsainas G, Mathias M, McMillan L, Ramalhinho MG, Rehermann B, Rosshart SR, Searle JB, Shiao MS, Solano E, Svenson KL, Thomas-Laemont P, Threadgill DW, Queija JV, Weinstock GM, Pomp D, Churchill GA, de Villena FPM. 2016. R2d2 drives selfish sweeps in the house mouse. Molecular Biology and Evolution 33:1381-1395.
Ceddia RP, Lee DK, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuiness OP, Gannon M, Breyer RM. 2016. The PGE2 EP3 receptor regulates diet-induced adiposity in male mice. Endocrinology 157:220-232.
2015
Campbell KJ, Beek J, Eason CT, Glen AS, Godwin G, Gould F, Holmes ND, Howald GR, Madden FM, Ponder JB, Threadgill DW, Wegmann AS, Baxter GS. 2015. The next generation of rodent eradications: innovative technologies and tools to improve species specificity and increase their feasibility on islands. Biological Conservation 185:47-58.
Didion JP, Morgan AP, Clayshulte AM, Mcmullan RC, Yadgary L, Petkov PM, Bell TA, Gatti DM, Crowley JJ, Hua K, Aylor DL, Bai L, Calaway M, Chesler EJ, French JE, Geiger TR, Gooch TJ, Garland T Jr, Harrill AH, Hunter K, McMillan L, Holt M, Miller DR, O'Brien DA, Paigen K, Pan W, Rowe LB, Shaw GD, Simecek P, Sullivan PF, Svenson KL, Weinstock GM, Threadgill DW, Pomp D, Churchill GA, Pardo-Manuel de Villena F. 2015. A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2. PLoS Genetics 11:31004850.
Scheving LA, Zhang X, Stevenson MC, Threadgill DW, Russell WE. 2015. Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice. American Journal of Physiology: Gastrointestinal and Liver Physiology 308:G364-377.
Church RJ, Gatti DM, Urban TJ, Long N, Yang X, Shi Q, Eaddy JS, Mosedale M, Ballard S, Churchill GA, Navarro V, Watkins PB, Threadgill DW, Harrill AH. 2015. Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice. Food and Chemical Toxicology 76:19-26.
Crowley JJ, Zhabotynsky V, Sun W, Huang S, Pakatci IK, Kim Y, Wang JR, Morgan AP, Calaway JD, Aylor DL, Yun Z, Bell TA, Buus RJ, Calaway ME, Didion JP, Gooch TJ, Hansen SD, Robinson NN, Shaw GD, Spence JS, Quackenbush CR, Barrick CJ, Nonneman RJ, Kim K, Xenakis J, Xie Y, Valdar W, Lenarcic AB, Wang W, Welsh CE, Fu CP, Zhang Z, Holt J, Guo Z, Threadgill DW, Tarantino LM, Miller DR, Zou F, McMillan L, Sullivan PF, Pardo-Manuel de Villena F. 2015. Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance. Nature Genetics 47:353-360.
Song X, Fan PD, Bantikassegn A, Guha U, Threadgill DW, Varmus H, Politi K. 2015. ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas. Cancer Research 75:1035-1045.
Gralinski LE, Ferris MT, Aylor DL, Whitmore AC, Green R, Frieman M, Deming D, Menachery VD, Miller D, Buus RJ, Bell TA, Churchill G, Threadgill DW, Katze MG, McMillan L, Valdar W, Heise MT, de Villena FPM, Baric RS. 2015. Genome wide identification of SARS-CoV susceptibility loci using the Collaborative Cross. PLoS Genetics 11:e1005504.
Scheving LA, Zhang X, Stevenson MC, Weintraub MA, Abbasi A, Clarke AM, Threadgill DW, Russell WE. 2015. Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis. Am J Physiol Gastrointest Liver Physiol 309:G942-54.
2014
Phillippi J, Xie Y, Miller DR, Bell TA, Zhang Z, Lenarcic AB, Aylor DL, Krovi SH, Threadgill DW, Pardo-Manuel de Villena F, Wang W, Valdar W, Frelinger JA. 2014. Using the emerging Collaborative Cross to probe the immune system. Genes and Immunity 15:38-46.
Scheving L, Zhang X, Garcia O, Wang R, Stevenson M, Threadgill DW, Russell W. 2014. Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice. American Journal of Physiology: Gastrointestinal and Liver Physiology 306:G370-381.
Large MJ, Wetendorf M, Lanz RB, Hartig SM, Creighton CJ, Mancini MA, Kovanci E, Lee KF, Threadgill DW, Lydon JP, Jeong JW, DeMayo FJ. 2014. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genetics 10:e1004451.
Donohoe DR, Holley D, Collins LB, Montgomery SA, Whitmore AC, Hillhouse A, Curry KP, Renner SW, Tillotson C, Ryan EP, Godfrey V, Heise MT, Threadgill DS, Swenberg JA, Threadgill DW, Bultman SJ. 2014. A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner. Cancer Discovery 4:1387-1397.
Didion JP, Buus RJ, Naghashfar Z, Threadgill DW, Morse HC, Pardo-Manuel de Villena F. 2014. SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy. BMC Genomics 15:847.
2013
Saito K, Horiuchi K, Kimura T, Mizuno S, Yoda M, Morioka H, Akiyama H, Threadgill DW, Okada Y, Toyama Y, Sato K. 2013. Conditional inactivation of TNFa-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones. PLoS ONE 8:e54853.
Ferris MT, Aylor DL, Bottomly D, Whitmore AC, Aicher LD, Bell TA, Bradel-Tretheway B, Bryan JT, Buus RJ, Gralinski LE, Haagmans BL, McMillan L, Miller DR, Rosenzweig E, Valdar W, Wang J, Churchill GA, Threadgill DW, McWeeney SK, Katze MG, de Villena FPM, Baric RS, Heise MT. 2013. Modeling host genetic regulation of influenza pathogenesis in the Collaborative Cross. PLoS Pathogens 9:e1003196.
Neufert C, Becker C, Tureci O, Waldner MJ, Backert I, Floh K, Atreya I, Leppkes M, Jefremow A, Vieth M, Schneider-Stock R, Klinger P, Greten F, Threadgill DW, Sahin U, Neurath MF. 2013. Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK. Journal Clinical Investigation 123:1428-1443.
DeSimone MC, Rathmell WK, Threadgill DW. 2013. Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis and ATM-mediated DNA damage response. Journal of the National Cancer Institute 105:1355-1364.
Bautz DJ, Broman KW, Threadgill DW. 2013. Identification of a novel polymorphism in X-linked sterol-4-alpha-carboxylate 3-dehydrogenase (Nsdhl) associated with reduced HDL cholesterol levels in I/LnJ mice. G3: Genes, Genomes and Genetics 3:1819-1825.
2012
Eversley CD, Xie Y, Pearsall RS, Threadgill DW. 2012. Mapping six new Susceptibility to Colon Cancer (Scc) loci using a mouse inter-specific backcross. G3: Genes, Genomes and Genetics 2:1577-1584.
Welsh CE, Miller DR, Manly KF, Wang J, McMillan L, Morahan G, Mott R, Iraqi FA, Threadgill DW, Pardo-Manuel de Villena F. 2012. Status and access to the Collaborative Cross population. Mammalian Genome 23:706-712.
Threadgill DW, Churchill GA. 2012. Ten years of the Collaborative Cross. Genetics 190:291-294.
Bottomly D, Ferris MT, Aicher LD, Rosenzweig E, Whitmore A, Aylor DL, Haagmans BL, Gralinski LE, Bradel-Tretheway BG, Bryan JT, Threadgill DW, de Villena FP-M, Baric RS, Katze MG, Heise M, McWeeney SK. 2012. Expression quantitative trait loci for extreme host response to influenza A in pre-Collaborative Cross mice. G3: Genes, Genomes and Genetics 2:213-221.
Iraqi FA, Mahajne M, Salaymah Y, Didion JP, Fu C-P, Gooch TJ, Hansen SD, McMillan L, Manly KF, Miller DR, de Villena FP-M, Shaw GD, Spence JS, Threadgill DW, Wang J, Welsh CE, Morahan G, Balmer L, Pettit K, Hall M and The Collaborative Cross Consortium. 2012. The genome architecture of the collaborative cross mouse genetic reference population. Genetics 190:389-401 (Cover Figure).
Kelada SNP, Aylor DL, Peck B, Tavarez U, Buus R, Miller DR, Chesler E, Threadgill DW, Churchill GA, de Villena FPM, Collins FS. 2012. Genetic analysis of hematological parameters in incipient lines of the collaborative cross. G3: Genes, Genomes and Genetics 2:157-165 (Cover Figure).
Chen J, Chen JK, Nagai K, Plieth D, Tan M, Lee TC, Threadgill DW, Neilson EG, Harris RC. 2012. EGFR signaling promotes TGFβ-dependent renal fibrosis. Journal of the American Society of Nephrology 23:215-224.
Rinella ES, Bankaitis ED, Threadgill DW. 2012. Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer. Cancer Biology and Therapy 13:130-137.
Crowley JJ, Kim Y, Szatkiewicz JP, Pratt AL, Quackenbush CR, Adkins DE, van den Oord E, Bogue MA, Yang H, Churchill G, Wang W, Threadgill DW, de Villena FPM, McLeod HL, Sullivan PF. 2012. Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice. Mammalian Genome 23:322-335.
Franzke CW, Cobzaru C, Triantafyllopoulou A, Loeffek S, Horiuchi K, Threadgill DW, Kurz T, van Rooijen N, Bruckner-Tuderman L, Blobel CP. 2012. Epidermal ADAM17 maintains skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. Journal of Experimental Medicine 209:1105-1119.
Rinella ES, Threadgill DW. 2012. Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials. PLoS ONE 7:e39552.
Ardito CA, Grüner BM; Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, DelGiorno KE, Halbrook CJ, Carpenter ES, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou G-Y, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC and Siveke JT. 2012. EGF Receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell 22:304-317.
Mustafi R, Dougherty U, Shah H, Dehghan H, Gliksberg A, Wu J, Zhu H, Joseph L, Hart J, Dive C, Fichera A, Threadgill DW, Bissonnette M. 2012. Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. Carcinogenesis 33:1930-1939.
2011
Threadgill DW, Miller DR, Churchill GA, Pardo-Manuel de Villena F. 2011. The Collaborative Cross: a recombinant inbred mouse population for the systems genetic era. ILAR Journal 52:24-31.
Schughart K, Arends D, Andreux P, Balling R, Beyer A, Bezerianos A, Brockmann GA, Crusio WE, Campbell-Tofte J, Denny P, Falcon-Perez JM, Forejt J, Franken P, Hovatta I, Iraqi F, Jansen RC, Kaczmarek L, Kas MJ, Kashofer K, Knapska E, Kolisis F, Kõks S, Lammert F, Möller S, Montagutelli X, Morahan G, Mott R, Pfoertner S, Prins P, Przewlocki R, Ranki A, Santos J, Rihet P, Schalkwyk L, Smit AB, Swertz M, Threadgill DW, Vasar E, Zatloukal K. 2011. SYSGENET: a meeting report from a new European network for systems genetics. Mammalian Genome 21:331-336.
Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, DeSimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I. 2011. Inter-strain differences in the liver effects of trichloroethylene in a multi-strain panel of inbred mice. Toxicological Sciences 120: 206-217.
Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Calaway JD, Didion JD, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SNP, Collins F, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill DW, de Villena FP-M, Churchill GA. 2011. Genetic analysis of complex traits in the emerging collaborative cross. Genome Research 21:1213-1222.
Kim K, Lee H, Threadgill DW, Lee DK. 2011. Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary. Biochem Biophys Res Comm 405: 319-324.
Zhang X, Tamasi J, Lu X, Zhu J, Chen H, Tian X, Lee TC, Threadgill DW, Kream BE, Kang Y, Partridge NC, Qin L. 2011. Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo. Journal of Bone Mineral Research 26:1022-1034.
Mathes WF, Aylor DL, Miller DR, Churchill GA, Chesler EJ, Pardo Manuel de Villena F, Threadgill DW, Pomp D. 2011. Architecture of energy balance traits in emerging lines of the Collaborative Cross. American Journal of Physiology - Endocrinology and Metabolism 300:E1124-1134.
Gatti DM, Lu L, Williams RW, Sun W, Wright FA, Threadgill DW, Rusyn I. 2011. MicroRNA expression in the livers of inbred mice. Mutation Research 714:126-133.
Bollée G, Flamant M, Schordan S, Fligny C, Rumpel E, Milon M, Schordan E, Sabaa N, Vandermeersch S, Galaup A, Rodenas A, Casal I, Sunnarborg SW, Salant DJ, Kopp JB, Threadgill DW, Quaggin SE, Dussaule JC, Germain S, Mesnard L, Endlich K, Bouchiex C, Bellenfant X, Callard P, Endlich N, Tharaux PL. 2011. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nature Medicine 17:1242-1250.
2010
Rusyn I, Gatti DM, Wiltshire T, Kleeberger SR, Threadgill DW. 2010. Toxicogenetics: population-based testing of drug and chemical safety in mouse models. Pharmacogenomics 11:1127-1136.
Mascia F, Cataisson C, Lee TC, Threadgill DW, Mariani V, Amerio P, Chandrasekhara C, Souto Adeva G, Girolomoni G, Yuspa SH, Pastore S. 2010. EGFR regulates the expression of keratinocyte derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo. Journal of Investigative Dermatology 130:682-693.
Zhang Z, Pascuet E, Hueber PA, Chu L, Bichet DG, Lee TC, Threadgill DW, Goodyer P. 2010. Targeted inactivation of EGF receptor inhibits renal collecting duct development and function. Journal American Society of Nephrology 21:573-578.
LaMerrill MA, Gordon RR, Hunter KW, Threadgill DW, Pomp D. 2010. Dietary fat alters pulmonary metastasis of mammary cancers through cancer autonomous and non-autonomous changes in gene expression. Clinical and Experimental Metastasis 27:107-116.
LaMerrill MA, Harper R, Birnbaum LS, Cardiff RD, Threadgill DW. 2010. Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence. Environmental Health Perspectives 118:596-601.
Powell CL, Bradford BU, Craig CP, Tsuchiya M, Uehara T, O-Connell TM, Pogribny IP, Melnyk S, Koop DR, Bleyle L, Threadgill DW, Rusyn I. 2010. Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicological Sciences 115:131-139.
Gordon RR, LaMerrill MA, Hunter KW, Sorensen P, Threadgill DW, Pomp D. 2010. Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis. Clinical and Experimental Metastasis 27:279-293.
Eversley CD, Clark T, Xie Y, Steigerwalt J, Bell TA, de Villena FP, Threadgill DW. 2010. Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross. BMC Genetics 11:98-103.
2009
Maklad A, Nicolai JR, Bischel KJ, Evenson JE, Lee TC, Threadgill DW, Hansen LA. 2009. The EGFR is required for proper innervation to the skin. Journal of Investigative Dermatology 129:690-698.
Pan F, McMillan L, Pardo-Manuel de Villena F, Threadgill DW, Wang W. 2009. TreeQA: Quantitative genome wide association mapping using local perfect phylogeny trees. Proceedings of the 14th Pacific Symposium on Biocomputing (PSB) 2009:415-426.
Zhang Q, Wang W, McMillan L, Pardo-Manuel de Villena F, Threadgill DW. 2009. Inferring genome-wide mosaic structure. Proceedings of the 14th Pacific Symposium on Biocomputing (PSB) 2009:150-161.
Lee TC, Threadgill DW. 2009. Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor. Genesis 47:85-92.v
Gatti DM, Harrill AH, Wright FA, Threadgill DW, Rusyn I. 2009. Replication and narrowing of gene expression quantitative trait loci using inbred mice. Mammalian Genome 20:437-446.
Munger SC, Aylor DL, Syed HA, Magwene PM, Threadgill DW, Capel B. 2009. Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. Genes and Development 23:2521-2536.
Dougherty U, Cerasi D, Taylor I, Kocherginsky M, Tekin U, Badal S, Aluri L, Sehdev A, Cerda S, Mustafi R, Delgado J, Joseph L, Zhu H, Hart J, Threadgill DW, Fichera A, Bissonnette M. 2009. Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-alpha and PTGS2. Clinical Cancer Research 15:6780-6789 (Cover Figure).
LaMerrill M, Baston DS, Denison MS, Birnbaum LS, Pomp D, Threadgill DW. 2009. Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. Am J Physiol-Endocrinology and Metabolism 296:E203-210.
Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW. 2009. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Research 19:1507-1515.
Pysz MA, Leontieva OV, Bateman NW, Uronis JM, Curry KJ, Threadgill DW, Janssen KP, Robine S, Velcich A, Augenlicht L, Black AR, Black JD. 2009. PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Experimental Cell Research 315:1415-1428.
Dackor J, Li M, Threadgill DW. 2009. Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor. Mammalian Genome 20:339-349 (Cover Figure).
LaMerrill MA, Kurvilla BS, Pomp D, Birnbaum LS, Threadgill DW. 2009. Dietary fat alters body composition, mammary development and P450 induction following maternal TCDD exposure in DBA/2J mice that express low responsive aryl hydrocarbon receptors. Environmental Health Perspectives 117:1414-1419.
Harrill AH, Ross PK, Threadgill DW, Rusyn I. 2009. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicological Sciences 110:235-243.
Barrick CJ, Roberts RB, Rojas M, Rajamannan NM, Suitt CB, O’Brien KD, Smyth SS, Threadgill DW. 2009. Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. American Journal of Physiology-Heart and Circulation 297:H65-75.
Dackor J, Caron KM, Threadgill DW. 2009. Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles. Genetics 183:207-218.
Barrick CJ, Dong A, Waikel R, Corn D, Yang F, Threadgill DW, Smyth SS. 2009. Parent-of-origin effects on cardiac response to pressure overload in mice. American Journal of Physiology-Heart and Circulation 297:H1003-1009.
Lee DK, Yu M, Lee E, Kim H, Yang Y, Paniccia C, Kim K, Kurie JM, Threadgill DW. 2009. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in the intestinal epithelium. Journal Clinical Investigation 119:2702-2713.
Carroll I, Threadgill DW, Threadgill DS. 2009. The gastrointestinal microbiome: a malleable third genome in mammals. Mammalian Genome 20: 395-403.
Halladay A, Amaral D, Aschner M, Bolivar V, Bowman A, DiCicco-Bloom E, Hyman S, Keller F, Lein P, Pessah I, Restifo L, Threadgill DW. 2009. Animal models of autism spectrum disorders: information for neurotoxicologists. Neurotoxicology 30:811-821.
Fiske WH, Threadgill DW, Coffey RJ. 2009. ERBBs in the gastrointestinal tract: recent progress and new perspectives. Experimental Cell Research 315:583-601.
Wang W, McMillan L, Threadgill DW, Pardo-Manuel de VIllena F. 2009. ‘Efficient data-mining methods enabling genome-wide computing’ in Kargupta H, Han J, Yu PS, Motwani, Jumar V (ed), Next Generation of Data Mining, Chapman and Hall, Boca Raton.
2008
Barrick CJ, Yu M, Chao H-H, Threadgill DW. 2008. Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice. Toxicology and Applied Pharmacolgy 228:315-325.
Pan F, Yang L, McMillan L, Pardo-Manuel de Villena F, Threagill DW, Wang W. 2008. Quantitative association analysis using tree hierarchies. Proceedigns of the 7th IEEE International Conference on Data Mining (ICDM) 2008.
Gordon R, Hunter KW, LaMerrill M, Threadgill DW, Pomp D. 2008. Genotype X diet interactions in mice predisposed to mammary cancer: II. tumors and metastasis. Mammalian Genome 19:179-189.
Chesler EJ, Miller DR, Branstetter LR, Galloway L, Jackson BL, Philip VM, Voy BH, Culiat CT, Threadgill DW, Williams RW, Churchill GA, Johnson DK, Manly KF. 2008. The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics. Mammalian Genome 19:382-389 (Cover Figure).
Zhang Q, Wang W, McMillan L, Prins J, Pardo-Manuel de Villena F, Threadgill DW. 2008. Genotype sequence segmentation: handling constraints and noise. Proceedings of the 8th Workshop on Algorithms in Bioinformatics (WABI), Lecture Notes in Computer Science 5251:271-283.
Abate-Shen C, Brown PH, Colburn NH, Gerner EW, Green JE, Lipkin M, Nelson WG, Threadgill DW. 2008. The untapped potential of genetically-engineered mouse models in chemoprevention research: opportunities and challenges. Cancer Prevention Research 1:161-166.
Threadgill DW. 2008. Down’s Syndrome: the paradox of a tumor repressor. Nature 452:21-22.
Radiloff D, Rinella E, Threadgill DW. 2008. Modeling cancer patient populations in mice: complex genetics and environmental factors. Drug Discovery Today: Disease Models 4:83-88.
2007
Barrick CJ, Rojas M, Schoonhoven R, Smyth SS, Threadgill DW. 2007. Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal and background dependent development of concentric left ventricular hypertrophy. American Journal Physiology-Heart and Circulation 292:2119-2130.
Moy SS, Nadler JJ, Young NB, Perez A, Holloway LP, Barbaro RP, Barbaro JR, Wilson LM, Threadgill DW, Lauder JM, Magnuson TR, Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of ten inbred strains. Behavioural Brain Research 176: 4-20.
Chi Y-Y, Ibrahim JG, Bissahoyo AC, Threadgill DW. 2007. Baysian hierarchical modeling for time course microarray experiments. Biometrics 63:496-504.
Hsieh M, Lee D, Panigone S, Horner K, Chen R, Lee DC, Threadgill DW, Conti M. 2007. LH-dependent activation of the EGF network is essential for ovulation. Molecular and Cellular Biology 27:1914-1924.
Gatti D, Maki A, Chesler EJ, Kirova R, Lu L, Manly K, Qu Y, Williams RW, Perkins A, Langston MA, Threadgill DW, Rusyn I. 2007. Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology 46:548-557.
Kaiser S, Park Y, Franklin J, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga A, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Roberts RB, Bissahoyo AC, Gonzales F, Bloom G, Eschrich S, Carter SL, Aronow J, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden JM, Dove WF, Threadgill DW, Yeatman T, Coffey RJ, Aronow BJ. 2007. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biology 8:R131.1-R131.26.
Roberts A, McMillan L, Wang W, Parker J, Rusyn I, Threadgill DW. 2007. Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows. Bioinformatcs 23:i401-i407.
Huang H, Eversley CD, Threadgill DW, Zou F. 2007. Bayesian multiple quantitative trait loci mapping for complex traits using markers of the entire genome. Genetics 176:2529-2540.
Roberts A, Pardo-Manuel de Villena F, Wang W, McMillan L, Threadgill DW. 2007. The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics. Mammalian Genome 18:473-481.
Dackor J, Strunk KE, Wehmeyer MM, Threadgill DW. 2007. Altered trophoblast proliferation is insufficient to cause placental dysfunction in Egfr null embryos. Placenta 28:1211-1218.
Uronis JM, Herfarth HH, Rubinas TC, Bissahoyo AC, Hanlon K, Threadgill DW. 2007. Flat colorectal cancers are genetically determined and progress to invasive cancer without going through a polypoid stage. Cancer Research 67:11594-11600 (Cover Figure).
Pan F, Roberts A, McMillan L, Pardo-Manuel de Villena F, Threadgill DW, Wang W. 2007. Sample selection for maximal diversity. Proceedings of the 7th IEEE International Conference on Data Mining (ICDM) 2007:262-271.
2006
Alexander AD, Orcutt RP, Henry JC, Baker J, Bissahoyo AC, Threadgill DW. 2006. Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment. Mammalian Genome 17:1093-1104.
Rinella ES, Eversley C, Carroll IM, Andrus JM, Threadgill DW, Threadgill DS. 2006. Human epithelia-specific response to pathogenic Campylobacter jejuni. FEMS Microbioogy Letters 262:236-243.
Syed HA, Threadgill DW. 2006. Enhanced oligonucleotide microarray labeling and hybridization. BioTechniques 41:685-686.
Nadler JJ, Zou F, Huang H, Moy SS, Lauder J, Crowley JN, Threadgill DW, Wright FA, Magnuson TR. 2006. Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype. Genetics 174:1229-1236.
Roberts RB, Thompson CL, Lee D, Mankinen RW, Sancar A, Threadgill DW. 2006. Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice. Journal Circadian Rhythms 4:15-20.
Threadgill DW. 2006. Meeting report for the 4th annual complex trait consortium meeting: from QTLs to systems genetics. Mammalian Genome 17:2-4.
Threadgill DW. 2006. ‘The collaborative cross: a unique mouse model resources for multi-variant QTL analysis of agriculturally important traits’ in Valente BD, de Morais OR and Ventura RV (organizers), Proceedings of the 8th World Congress on Genetics Applied to Livestock Production, Belo Horizonte, Brazil.
2005
Threadgill DW. 2005. Metastatic potential as a heritable trait. Nature Genetics 37:1026-1027.
Roberts RB, Threadgill DW. 2005. ‘The mouse in biomedical research’ in Eisen EJ (ed), The Mouse in Animal Genetics and Breeding Research, Imperial College Press, London.
Franklin JL, Yoshiura K, Dempsey PJ, Bogatcheva G, Jeyakumar L, Meise S, Pearsall RS, Threadgill DW, Coffey RJ. 2005. Identification of MAGI-3 as a transforming growth factor-a binding protein. Experimental Cell Research 303:457-470.
Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin N, Langston MA, Threadgill DW, Manly KF, Williams RW. 2005. Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nature Genetics 37:233-242.
Zou F, Gelfond JAL, Airey DC, Lu L, Manly KF, Williams RW, Threadgill DW. 2005. Quantitative trait locus analysis using recombinant inbred intercrosses (RIX): theoretical and empirical considerations. Genetics 170:1299-1311.
Genther Williams SM, Disbrow G, Schlegel R, Lee D, Threadgill DW, Lambert PF. 2005. Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high risk human papillomavirus oncogene. Cancer Research: 65:6534-6542.
Bissahoyo A, Pearsall RS, Hanlon KE, Amann V, Hicks D, Godfrey VL, Threadgill DW. 2005. Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet. Toxicological Sciences 88:340-345.
Fujimoto H, Wislez M, Zhang J, Iwanaga K, Dackor J, Hanna AE, Kalyankrishna S, Cody DD, Price RE, Sato M, Shay JW, Minna JD, Peyton M, Tang X, Massarelli E, Herbst R, Threadgill DW, Wistuba I, Kurie JM. 2005. High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Research 65:11478-11485.
Mrosovsky N, Redlin U, Roberts RB, Threadgill DW. 2005. Masking in Waved-2 mice: lack of evidence for EGF receptor control of locomotion. Chronobiology International 22:963-974.
2004
Roberts RB, Arteaga CL, Threadgill DW. 2004. Modeling the entire patient: predicting side-effects of targeted therapies with the genetically engineered mouse. Cancer Cell 5:115-120.
Strunk K, Amann V, Threadgill DW. 2004. Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be molecularly partitioned. Genetics 167:1821-1832.
Lee D, Pearsall RS, Das S, Dey SK, Godfrey VL, Threadgill DW. 2004. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Molecular and Cellular Biology 24:8907-8916.
Lee D, Cross SH, Strunk KE, Morgan JE, Bailey CL, Jackson IJ, Threadgill DW. 2004. Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mammalian Genome 15:525-536 (Cover Figure).
Hahn H, Nitzki F, Schorban T, Hemmerlein B, Threadgill D, Rosemann M. 2004. Genetic mapping of a Ptch-associated rhabdomyosarcoma susceptibility locus on mouse Chromosome 2. Genomics 84:853-858.
Wilson W, Pardo-Manueal de Villena F, Lyn-Cook BD, Chatterjee PK, Gilmore RC, Valladeras IC, Wright CC, Threadgill DW, Grant DJ. 2004. Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15. Genomics 84:707-714.
Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrenttini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschnepper CF, Doerge RW, Faber CR, Forejt J, Gaile D, Garlw SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu WK, de Hann G, hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jjepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusiss A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Modil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O’Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Qi ZH, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomure K, Shou SM, Sillanpaa MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill DW, Toth LA, Valdar W, de Villena FPM, Warden C, Whatley S, Williams RW, Wiltshire T, Yi NJ, Zhang DB, Zhang M, Zou F. 2004. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics 36:1133-1137.
Lee D, Threadgill DW. 2004. Investigating gene function using mouse models. Current Opinion in Genetics and Development 14:246-252.
Threadgill DW, Hunter KW, Zou F, Manly KF. 2004. ‘Cancer modifiers: detection, localization and identification’ in Holland E (ed), Mouse Models of Cancer, John Wiley & Sons, New York.
2003
Fitch KR, McGowan KA, van Raamsdonk CD, Fuchs H, Lee D, Puech A, Herault Y, Threadgill DW, Hrabe de Angelis M, Barsh GS. 2003. Genetics of dark skin in mice. Genes and Development 17:214-28.
Williams RW, Flaherty L, Threadgill DW. 2003. The math of making mutant mice. Genes, Brain and Behavior 2:191-200.
Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Dermant P, Doerge RW, Elliot RW, Farber CR, Flaherty L, Flint J, Gershenfeld H, Gibson JP, Gu J, Gu W, Himmelbauer H, Hitzemann R, Hsu HC, Hunter K, Iraqi FF, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittlemann G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang HG, Zou F. 2003. The nature and identification of quantitative trait loci: a community’s view. Nature Reviews Genetics 4:911-916.
2002
Roberts RB, Min L, Washington MK, Olsen SJ, Settle SH, Coffey RJ, Threadgill DW. 2002. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci USA 99:1521-1526.
Threadgill DW, Hunter KW, and Williams RW. 2002. Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. Mammalian Genome 13:175-178.
Williams RW, Broman KW, Cheverud JM, Churchill GA, Hitzemann RW, Hunter KW, Mountz JD, Pomp P, Reeves RH, Schalkwyk LC, Threadgill DW. 2002. A collaborative cross for high-precision complex trait analysis: workshop report of the Collaborative Cross planning committee.
Boykin R, Threadgill DW. 2002. Genetics definitions in: Child Development, Vol One in the Macmillan Psychology Reference Series.
2001
Reiter JL, Threadgill DW, Eley GD, Strunk KE, Danielsen AJ, Schell-Sinclair C, Pearsall RS, Green PJ, Yee D, Lampland AL, Balasubramaniam S, Crossley TO, Magnuson TR, James CD, Maihle NJ. 2001. Comparative genomic sequence analysis and isolation of human and mouse alternative Egfr transcripts encoding truncated receptor isoforms. Genomics 71:1-20.
Chaurand P, Dague BB, Pearsall RS, Threadgill DW, Caprioli RM. 2001. Profiling proteins from azoxymethane-induced colon tumors at the molecular level by MALDI mass spectrometry. Proteomics 1:1320-1326.
2000
Coffey RJ, Threadgill DW. 2000. Microarray foray. Breast Cancer Research 2:8-9.
Denning MF, Dlugosz AA, Cheng C, Dempsey PJ, Coffey RJ, Threadgill DW, Magnuson T, Yuspa SH. 2000. Cross-talk between epidermal growth factor receptor and protein kinase C during calcium-induced differentiation of keratinocytes. Experimental Dermatology 9:192-199.
Pre-2000
McQuain M, Duncavage EJ, Pearsall RS, Threadgill DW, Coffey RJ, Haselton F. 1999. Quantitative comparison of protocols for DNA attachment and hybridization to glass. Annals of Biomedical Engineering 1:S124.
Nishimura H, Yerkes E, Hohenfellner K, Miyazaki Y, Ma J, Hunley TE, Yoshida H, Ichiki T, Threadgill D, Phillips JA 3rd, Hogan BM, Fogo A, Brock JW 3rd, Inagami T, Ichikawa I. 1999. Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Molecular Cell 3:1-10.
Hansen LA, Alexander N, Hogan ME, Sundberg JP, Dlugosz A,Threadgill DW, Magnuson T, Yuspa SH. 1997. Genetically null mice reveal a central role for epidermal growth factor receptor in the maturation of the hair follicle and normal hair development. American Journal of Pathology 150:1959-1975.
Threadgill DW, Yee D, Matin A, Nadeau JH, Magnuson T. 1997. Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain. Mammalian Genome 8:390-393.
Threadgill DW, Matin A, Yee D, Carrasquillo MM, Henry KR, Rollins KG, Nadeau JH, Magnuson T. 1997. SSLPs to map genetic differences between the 129 inbred strains and closed-colony random bred CD-1 mice. Mammalian Genome 8:441-442.
Dlugosz AA, Hansen L, Cheng C, Alexander N, Denning MF, Threadgill DW, Magnuson T, Coffey RJ, Yuspa SH. 1997. Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras (Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras. Cancer Research 57:3180-3188.
Denning MF, Dlugosz AA, Threadgill DW, Magnuson T, Yuspa SH. 1996. Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase Cg. Journal of Biological Chemistry 271:5325-5331.
Tong BJ, Das SK, Threadgill DW, Magnuson T, Dey SK. 1996. Differential expression of the full-length and truncated forms of the epidermal growth factor receptor in the preimplantation mouse uterus and blastocyst. Endocrinology 137:1492-1496.
Threadgill DW, Dlugosz AA, Hansen L, Tennenbaum T, Lichti U, Yee D, LeMantia C, Mourton T, Herrup K, Harris RC, Barnard JA, Yuspa SH, Coffey RJ, Magnuson T. 1995. Targeted disruption of mouse EGF-receptor: effect of genetic background on mutant phenotype. Science 269:230-234.
Threadgill DW, Yee D, Thompson C, Magnuson T. 1995. Epidermal growth factor receptor deficiency results in periimplantation lethality in mouse. Proceedings of the Serono Symposium on Molecular and Cellular Aspects of Periimplantation Processes, 231-235.
Threadgill DS, Threadgill DW, Moll YD, Weiss JA, Zhang N, Davey HW, Wildeman AG, Womack JE. 1994. Syntenic assignment of human chromosome 1 homologous loci in the bovine. Genomics 22:626-630.
Gallagher DS, Threadgill DW, Ryan AM, Womack JE, Irwin DM. 1993. Physical mapping of the lysozyme gene family in cattle. Mammalian Genome 4:368-373.
Dietz AB, Georges M, Threadgill DW, Womack JE, Schuler LA. 1992. Somatic cell mapping, polymorphism, and linkage analysis of bovine prolactin-related proteins and placental lactogen. Genomics 14:137-143.
Nan Z, Threadgill DW, Womack JE. 1992. Synteny mapping in the bovine: genes from human chromosome 4. Genomics 14:131-136.
Sharan SK, Holdener-Kenny B, Threadgill DW, Magunson T. 1992. Genomic mapping within the albino-deletion complex using individual early postimplantation mouse embryos. Mammalian Genome 3:79-83.
Threadgill DW, Womack JE. 1991. Synteny mapping of human chromosome 8 loci in cattle. Animal Genetics 22:117-122. Gallagher DS, Threadgill DW, Jackson AP, Parham P, Womack JE. 1991. Somatic cell mapping of bovine clathrin light chain genes: identification of a new bovine syntenic group. Cytogenetics Cell Genetics 56:154-156.
Fries R, Threadgill DW, Hediger R, Gunawardana A, Blessing M, Jorcano JL, Stranzinger G, Womack JE. 1991. Mapping of bovine cytokeratin sequences to four different sites on three chromosomes. Cytogenetics Cell Genetics 57:135-141.
Georges M, Gunawardana A, Threadgill DW, Lathrop M, Olsaker I, Mishra A, Sargeant L, Schoeberlein A, Steele M, Terry C, Threadgill DS, Zhao X, Holm T, Fries R, Womack JE. 1991. Characterization of a set of variable number of tandem repeat markers conserved in Bovidae. Genomics 11:24-32.
Bishop MD, Tavakkol A, Threadgill DW, Simmen FA, Simmen RCM, Davis ME, Womack JE. 1991. Somatic cell mapping and restriction fragment length polymorphism analysis of bovine insulin-like growth factor 1 (IGF1). Journal of Animal Science 69:4306-4311.
Threadgill DW, Womack JE. 1990. Syntenic conservation between humans and cattle I: human chromosome 9. Genomics 8:22-28.
Threadgill DW, Adkison LR, Womack JE. 1990. Syntenic conservation between humans and cattle II: human chromosome 12. Genomics 8:29-34.
Threadgill DW, Womack JE. 1990. Genomic analysis of the major bovine milk protein genes. Nucleic Acids Research 18:6935-6942.
Threadgill DW, Fries R, Faber LK, Vassart G, Gunawardana A, Stranzinger G, Womack JE. 1990. The thyroglobulin gene is syntenic with the MYC and MOS proto-oncogenes and carbonic anhydrase II and maps to chromosome 14 in cattle. Cytogenetics Cell Genetics 53: 32-36.
Threadgill DW, Wilkemeyer M, Womack JE, Ledley FD. 1990. Localization of the murine methylmalonyl CoA mutase (Mut) locus on chromosome 17 by in situ hybridization. Cytogenetics Cell Genetics 53: 112-114.
Threadgill DW, Womack JE. 1988. Regional localization of mouse Abl and Mos proto-oncogenes by in situ hybridization. Genomics 3: 82-86.
